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Idiopathic Fatigue of Aging Conference
September 3-5, 2008, Bethesda, MD

Supported by: The National Institute on Aging, the John A. Hartford Foundation, and the American Geriatrics Society.

About the Conference

Fatigue is a common and disabling symptom in older adults that has been difficult to operationalize and assess. While some cases of fatigue can be attributed to specific diagnoses, idiopathic fatigue of aging may have multiple potential contributing mechanisms. Presenters focused on evidence from animal and human models to explore the relationships between energy production and utilization and fatigue. Other speakers discussed how inflammatory factors, muscle physiology, and specific diseases contribute to fatigue (see Conference Agenda). 

The conference objectives were to:  (1) bring together experts from aging, epidemiology, energy and metabolism and other fields to promote a better understanding of potential underlying mechanisms and implications for intervention; (2) present initial concepts and recommendations from the NIA Exploratory Workshop on Unexplained Fatigue in the Elderly; (3) identify important gaps in knowledge and priorities for further research; and (4) propose opportunities for collaborative studies, especially translational research between clinical and bench scientists and across disciplines.

Conference Planning Committee

Neil Alexander, MD
University of Michigan Medical School
Luigi Ferrucci, MD*
National Institute of Aging
Stephanie Studenski, MD, MPH
University of Pittsburgh
Basil A. Eldadah, MD, PhD*
National Institute on Aging, Division of Geriatrics and Clinical Gerontology
Susan Nayfield, MD, MSc*
National Institute of Health
George E. Taffet, MD
Baylor College of Medicine


Conference Report

Alexander NB, Taffet GE, Horne FM, Eldadah BA, Ferrucci L, Nayfield S, Studenski S. Bedside-to-Bench conference: research agenda for idiopathic fatigue and aging. J Am Geriatr Soc. 2010 May;58(5):967-75.

PowerPoint™ Presentations

Neil Alexander, MD
Francisco Andrade, PhD
Zeeshan Butt, PhD (abbreviated)
Francesco Celi, MD
Kong Chen, PhD, MSCI
Charles Cleeland, PhD
Robert Dantzer, DVM
Basil A. Eldadah, MD, PhD (abbreviated) *
Luigi Ferrucci, MD, PhD (1 and 2) *
Mariana Gerschenson, PhD
Bret Goodpaster, PhD
Evan Hadley, MD
Jane Kent-Braun, PhD
Donna Mancini, MD
Romain Meeusen, PhD (abbreviated)
Susan Nayfield, MD *
George E. Taffet, MD
Doug Wallace, PhD
Phyllis Zee, MD, PhD


*Denotes NIH representative